John Rubenstein, MD

What I Do

  • Current Title(s):
    • Nina Ireland Distinguished Professor in Child Psychiatry
    • Professor of Psychiatry
  • Biography Summary:
    • John Rubenstein, M.D., Ph.D., Researcher of basic science in the Department of Psychiatry at UCSF
  • First Year on UCSF Faculty: 1991
  • Education:
    • M.D. Stanford University, 1983
    • PhD. Stanford University, 1982
    • Pasteur Institute, Postdoctoral Fellowship in Developmental Biology
    • Stanford University, Residency in Adult Psychiatry
    • Stanford University, Residency in Child Psychiatry
  • Research Training:
    • 1972: Norman Shumway and Randall Morris, Stanford Medical School
    • 1973: Paul Wolf, Stanford Medical School
    • 1974: Arthur Kornberg and William Wickner, Stanford Medical School
    • 1975: A.T. Ganesan, Stanford Medical School
    • 1975-1977: David Clayton and Douglas Brutlag, Stanford Medical School
    • 1977: B.S. in Chemistry, Stanford University
    • 1977-1980: Harden McConnell, Stanford Department of Chemistry
    • 1980-1982: James Rothman, Stanford Medical School
    • 1982: Ph.D. in Biophysics, Stanford University
    • 1984-1986: Francois Jacob and Jean Francois Nicolas, Pasteur Institute, Paris
    • 1987-1988: Jack Barchas, Stanford Medical School
    • 1988-1991: Roland Ciaranello, Stanford Medical School
  • Clinical Expertise:
    • Developmental Disorders
  • Educational Expertise:
    • Developmental Neurobiology
  • Research Areas:
    • Development of the forebrain
  • University of California, San Francisco, Department of Psychiatry 
    • Box 2611 , Mission Bay 284C 
    • University of California, San Francisco
    • San Francisco, CA. 94143 - 2611 
  • Phone: (415) 476-7862,  Fax: (415) 502-7618 or (415) 476-7884,  
  • Email:

Professional Biography

John Rubenstein, MD, Phd is a Professor in the Department of Psychiatry at the University of California San Francisco. He also serves as a Nina Ireland Distinguished Professor in Child Psychiatry at the Nina Ireland Laboratory of Developmental Neurobiology. His research focuses on the regulatory genes that orchestrate development of the forebrain.

In the mammalian embryo, the forebrain is the portion of the neural tube where primitive cells are organized to form the cerebral cortex, the basal ganglia and other components of the adult brain -- the structures of the human brain most involved in key functions such as speech, language, cognition and fine motor skills.

Rubenstein's lab has demonstrated the role of specific genes in regulating neuronal specification, differentiation, migration and axon growth during embryonic development and on through adult life. His work may help to explain some of the mechanisms underlying human neurodevelopmental disorders such as autism.


  1. Wu PR, Cho KKA, Vogt D, Sohal VS, Rubenstein JLR. The Cytokine CXCL12 Promotes Basket Interneuron Inhibitory Synapses in the Medial Prefrontal Cortex. Cereb Cortex. 2017 Sep 01; 27(9):4303-4313.
  2. Le TN, Zhou QP, Cobos I, Zhang S, Zagozewski J, Japoni S, Vriend J, Parkinson T, Du G, Rubenstein JL, Eisenstat DD. GABAergic Interneuron Differentiation in the Basal Forebrain Is Mediated through Direct Regulation of Glutamic Acid Decarboxylase Isoforms by Dlx Homeobox Transcription Factors. J Neurosci. 2017 Sep 06; 37(36):8816-8829.
  3. Hu JS, Vogt D, Lindtner S, Sandberg M, Silberberg SN, Rubenstein JLR. Coup-TF1 and Coup-TF2 control subtype and laminar identity of MGE-derived neocortical interneurons. Development. 2017 Aug 01; 144(15):2837-2851.
  4. Yang N, Chanda S, Marro S, Ng YH, Janas JA, Haag D, Ang CE, Tang Y, Flores Q, Mall M, Wapinski O, Li M, Ahlenius H, Rubenstein JL, Chang HY, Buylla AA, Südhof TC, Wernig M. Generation of pure GABAergic neurons by transcription factor programming. Nat Methods. 2017 Jun; 14(6):621-628.
  5. Chen YJ, Friedman BA, Ha C, Durinck S, Liu J, Rubenstein JL, Seshagiri S, Modrusan Z. Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types. Sci Rep. 2017 Mar 31; 7:45656.
  6. Gobius I, Morcom L, Suárez R, Bunt J, Bukshpun P, Reardon W, Dobyns WB, Rubenstein JL, Barkovich AJ, Sherr EH, Richards LJ. Astroglial-Mediated Remodeling of the Interhemispheric Midline Is Required for the Formation of the Corpus Callosum. Cell Rep. 2016 Oct 11; 17(3):735-747.
  7. Silberberg SN, Taher L, Lindtner S, Sandberg M, Nord AS, Vogt D, Mckinsey GL, Hoch R, Pattabiraman K, Zhang D, Ferran JL, Rajkovic A, Golonzhka O, Kim C, Zeng H, Puelles L, Visel A, Rubenstein JL. Subpallial Enhancer Transgenic Lines: a Data and Tool Resource to Study Transcriptional Regulation of GABAergic Cell Fate. Neuron. 2016 Oct 05; 92(1):59-74.
  8. Sandberg M, Flandin P, Silberberg S, Su-Feher L, Price JD, Hu JS, Kim C, Visel A, Nord AS, Rubenstein JLR. Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons. Neuron. 2016 Sep 21; 91(6):1260-1275.
  9. Sun Y, Pasca SP, Portmann T, Goold C, Worringer KA, Guan W, Chan KC, Gai H, Vogt D, Chen YJ, Mao R, Chan K, Rubenstein JL, Madison DV, Hallmayer J, Froehlich-Santino WM, Bernstein JA, Dolmetsch RE. A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients. Elife. 2016 Jul 26; 5.
  10. Notwell JH, Heavner WE, Darbandi SF, Katzman S, McKenna WL, Ortiz-Londono CF, Tastad D, Eckler MJ, Rubenstein JL, McConnell SK, Chen B, Bejerano G. TBR1 regulates autism risk genes in the developing neocortex. Genome Res. 2016 08; 26(8):1013-22.
  11. Puelles L, Medina L, Borello U, Legaz I, Teissier A, Pierani A, Rubenstein JL. Radial derivatives of the mouse ventral pallium traced with Dbx1-LacZ reporters. J Chem Neuroanat. 2016 Sep; 75(Pt A):2-19.
  12. Holloway AK, Bruneau BG, Sukonnik T, Rubenstein JL, Pollard KS. Accelerated Evolution of Enhancer Hotspots in the Mammal Ancestor. Mol Biol Evol. 2016 Apr; 33(4):1008-18.
  13. Prochazka J, Prochazkova M, Du W, Spoutil F, Tureckova J, Hoch R, Shimogori T, Sedlacek R, Rubenstein JL, Wittmann T, Klein OD. Migration of Founder Epithelial Cells Drives Proper Molar Tooth Positioning and Morphogenesis. Dev Cell. 2015 Dec 21; 35(6):713-24.
  14. Golonzhka O, Nord A, Tang PL, Lindtner S, Ypsilanti AR, Ferretti E, Visel A, Selleri L, Rubenstein JL. Pbx Regulates Patterning of the Cerebral Cortex in Progenitors and Postmitotic Neurons. Neuron. 2015 Dec 16; 88(6):1192-207.
  15. Lim JW, Donahoo AL, Bunt J, Edwards TJ, Fenlon LR, Liu Y, Zhou J, Moldrich RX, Piper M, Gobius I, Bailey TL, Wray NR, Kessaris N, Poo MM, Rubenstein JL, Richards LJ. EMX1 regulates NRP1-mediated wiring of the mouse anterior cingulate cortex. Development. 2015 Nov 01; 142(21):3746-57.
  16. Martinez-Ferre A, Lloret-Quesada C, Prakash N, Wurst W, Rubenstein JL, Martinez S. Fgf15 regulates thalamic development by controlling the expression of proneural genes. Brain Struct Funct. 2016 Jul; 221(6):3095-109.
  17. Ypsilanti AR, Rubenstein JL. Transcriptional and epigenetic mechanisms of early cortical development: An examination of how Pax6 coordinates cortical development. J Comp Neurol. 2016 Feb 15; 524(3):609-29.
  18. Parchem RJ, Moore N, Fish JL, Parchem JG, Braga TT, Shenoy A, Oldham MC, Rubenstein JL, Schneider RA, Blelloch R. miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability. Cell Rep. 2015 Aug 04; 12(5):760-73.
  19. Hoch RV, Lindtner S, Price JD, Rubenstein JL. OTX2 Transcription Factor Controls Regional Patterning within the Medial Ganglionic Eminence and Regional Identity of the Septum. Cell Rep. 2015 Jul 21; 12(3):482-94.
  20. Cesario JM, Landin Malt A, Deacon LJ, Sandberg M, Vogt D, Tang Z, Zhao Y, Brown S, Rubenstein JL, Jeong J. Lhx6 and Lhx8 promote palate development through negative regulation of a cell cycle inhibitor gene, p57Kip2. Hum Mol Genet. 2015 Sep 01; 24(17):5024-39.
  21. Bráz JM, Wang X, Guan Z, Rubenstein JL, Basbaum AI. Transplant-mediated enhancement of spinal cord GABAergic inhibition reverses paclitaxel-induced mechanical and heat hypersensitivity. Pain. 2015 Jun; 156(6):1084-91.
  22. Eckler MJ, Nguyen TD, McKenna WL, Fastow BL, Guo C, Rubenstein JLR, Chen B. Cux2-positive radial glial cells generate diverse subtypes of neocortical projection neurons and macroglia. Neuron. 2015 May 20; 86(4):1100-1108.
  23. Vogt D, Cho KKA, Lee AT, Sohal VS, Rubenstein JLR. The parvalbumin/somatostatin ratio is increased in Pten mutant mice and by human PTEN ASD alleles. Cell Rep. 2015 May 12; 11(6):944-956.
  24. Vogt D, Wu PR, Sorrells SF, Arnold C, Alvarez-Buylla A, Rubenstein JL. Viral-mediated Labeling and Transplantation of Medial Ganglionic Eminence (MGE) Cells for In Vivo Studies. J Vis Exp. 2015 Apr 23; (98).
  25. Ferran JL, Puelles L, Rubenstein JL. Molecular codes defining rostrocaudal domains in the embryonic mouse hypothalamus. Front Neuroanat. 2015; 9:46.
  26. Hoch RV, Clarke JA, Rubenstein JL. Fgf signaling controls the telencephalic distribution of Fgf-expressing progenitors generated in the rostral patterning center. Neural Dev. 2015 Mar 31; 10:8.
  27. Puelles L, Rubenstein JL. A new scenario of hypothalamic organization: rationale of new hypotheses introduced in the updated prosomeric model. Front Neuroanat. 2015; 9:27.
  28. Cho KK, Hoch R, Lee AT, Patel T, Rubenstein JL, Sohal VS. Gamma rhythms link prefrontal interneuron dysfunction with cognitive inflexibility in Dlx5/6(+/-) mice. Neuron. 2015 Mar 18; 85(6):1332-43.
  29. Nord AS, Pattabiraman K, Visel A, Rubenstein JL. Genomic perspectives of transcriptional regulation in forebrain development. Neuron. 2015 Jan 07; 85(1):27-47.
  30. Correa SM, Newstrom DW, Warne JP, Flandin P, Cheung CC, Lin-Moore AT, Pierce AA, Xu AW, Rubenstein JL, Ingraham HA. An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females. Cell Rep. 2015 Jan 06; 10(1):62-74.
  31. Eom TY, Stanco A, Guo J, Wilkins G, Deslauriers D, Yan J, Monckton C, Blair J, Oon E, Perez A, Salas E, Oh A, Ghukasyan V, Snider WD, Rubenstein JL, Anton ES. Differential regulation of microtubule severing by APC underlies distinct patterns of projection neuron and interneuron migration. Dev Cell. 2014 Dec 22; 31(6):677-89.
  32. Stanco A, Pla R, Vogt D, Chen Y, Mandal S, Walker J, Hunt RF, Lindtner S, Erdman CA, Pieper AA, Hamilton SP, Xu D, Baraban SC, Rubenstein JL. NPAS1 represses the generation of specific subtypes of cortical interneurons. Neuron. 2014 Dec 03; 84(5):940-53.
  33. Lee AT, Vogt D, Rubenstein JL, Sohal VS. A class of GABAergic neurons in the prefrontal cortex sends long-range projections to the nucleus accumbens and elicits acute avoidance behavior. J Neurosci. 2014 Aug 27; 34(35):11519-25.
  34. Tong LM, Djukic B, Arnold C, Gillespie AK, Yoon SY, Wang MM, Zhang O, Knoferle J, Rubenstein JL, Alvarez-Buylla A, Huang Y. Inhibitory interneuron progenitor transplantation restores normal learning and memory in ApoE4 knock-in mice without or with Aß accumulation. J Neurosci. 2014 Jul 16; 34(29):9506-15.
  35. Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16; 83(2):309-323.
  36. Rubenstein JL. Major progress towards elucidating brain wiring diagrams. J Comp Neurol. 2014 Jun 15; 522(9):1987-8.
  37. Pattabiraman K, Golonzhka O, Lindtner S, Nord AS, Taher L, Hoch R, Silberberg SN, Zhang D, Chen B, Zeng H, Pennacchio LA, Puelles L, Visel A, Rubenstein JL. Transcriptional regulation of enhancers active in protodomains of the developing cerebral cortex. Neuron. 2014 Jun 04; 82(5):989-1003.
  38. Vogt D, Hunt RF, Mandal S, Sandberg M, Silberberg SN, Nagasawa T, Yang Z, Baraban SC, Rubenstein JL. Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position. Neuron. 2014 Apr 16; 82(2):350-64.
  39. Southwell DG, Nicholas CR, Basbaum AI, Stryker MP, Kriegstein AR, Rubenstein JL, Alvarez-Buylla A. Interneurons from embryonic development to cell-based therapy. Science. 2014 Apr 11; 344(6180):1240622.
  40. Eckler MJ, Larkin KA, McKenna WL, Katzman S, Guo C, Roque R, Visel A, Rubenstein JL, Chen B. Multiple conserved regulatory domains promote Fezf2 expression in the developing cerebral cortex. Neural Dev. 2014 Mar 12; 9:6.
  41. Silbereis JC, Nobuta H, Tsai HH, Heine VM, McKinsey GL, Meijer DH, Howard MA, Petryniak MA, Potter GB, Alberta JA, Baraban SC, Stiles CD, Rubenstein JL, Rowitch DH. Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian brain. Neuron. 2014 Feb 05; 81(3):574-87.
  42. Nord AS, Blow MJ, Attanasio C, Akiyama JA, Holt A, Hosseini R, Phouanenavong S, Plajzer-Frick I, Shoukry M, Afzal V, Rubenstein JL, Rubin EM, Pennacchio LA, Visel A. Rapid and pervasive changes in genome-wide enhancer usage during mammalian development. Cell. 2013 Dec 19; 155(7):1521-31.
  43. Lee AT, Gee SM, Vogt D, Patel T, Rubenstein JL, Sohal VS. Pyramidal neurons in prefrontal cortex receive subtype-specific forms of excitation and inhibition. Neuron. 2014 Jan 08; 81(1):61-8.
  44. Howard MA, Rubenstein JL, Baraban SC. Bidirectional homeostatic plasticity induced by interneuron cell death and transplantation in vivo. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):492-7.
  45. Guo C, Eckler MJ, McKenna WL, McKinsey GL, Rubenstein JL, Chen B. Fezf2 expression identifies a multipotent progenitor for neocortical projection neurons, astrocytes, and oligodendrocytes. Neuron. 2013 Dec 04; 80(5):1167-74.
  46. Capra JA, Erwin GD, McKinsey G, Rubenstein JL, Pollard KS. Many human accelerated regions are developmental enhancers. Philos Trans R Soc Lond B Biol Sci. 2013 Dec 19; 368(1632):20130025.
  47. Mandal S, Stanco A, Buys ES, Enikolopov G, Rubenstein JL. Soluble guanylate cyclase generation of cGMP regulates migration of MGE neurons. J Neurosci. 2013 Oct 23; 33(43):16897-914.
  48. Zhao Y, Flandin P, Vogt D, Blood A, Hermesz E, Westphal H, Rubenstein JL. Ldb1 is essential for development of Nkx2.1 lineage derived GABAergic and cholinergic neurons in the telencephalon. Dev Biol. 2014 Jan 01; 385(1):94-106.
  49. Hansen DV, Lui JH, Flandin P, Yoshikawa K, Rubenstein JL, Alvarez-Buylla A, Kriegstein AR. Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences. Nat Neurosci. 2013 Nov; 16(11):1576-87.
  50. Ma T, Wang C, Wang L, Zhou X, Tian M, Zhang Q, Zhang Y, Li J, Liu Z, Cai Y, Liu F, You Y, Chen C, Campbell K, Song H, Ma L, Rubenstein JL, Yang Z. Subcortical origins of human and monkey neocortical interneurons. Nat Neurosci. 2013 Nov; 16(11):1588-97.
  51. Arguello A, Yang X, Vogt D, Stanco A, Rubenstein JL, Cheyette BN. Dapper antagonist of catenin-1 cooperates with Dishevelled-1 during postsynaptic development in mouse forebrain GABAergic interneurons. PLoS One. 2013; 8(6):e67679.
  52. Cai Y, Zhang Y, Shen Q, Rubenstein JL, Yang Z. A subpopulation of individual neural progenitors in the mammalian dorsal pallium generates both projection neurons and interneurons in vitro. Stem Cells. 2013 Jun; 31(6):1193-201.
  53. Hunt RF, Girskis KM, Rubenstein JL, Alvarez-Buylla A, Baraban SC. GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behavior. Nat Neurosci. 2013 Jun; 16(6):692-7.
  54. Miraoui H, Dwyer AA, Sykiotis GP, Plummer L, Chung W, Feng B, Beenken A, Clarke J, Pers TH, Dworzynski P, Keefe K, Niedziela M, Raivio T, Crowley WF, Seminara SB, Quinton R, Hughes VA, Kumanov P, Young J, Yialamas MA, Hall JE, Van Vliet G, Chanoine JP, Rubenstein J, Mohammadi M, Tsai PS, Sidis Y, Lage K, Pitteloud N. Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. Am J Hum Genet. 2013 May 02; 92(5):725-43.
  55. Nicholas CR, Chen J, Tang Y, Southwell DG, Chalmers N, Vogt D, Arnold CM, Chen YJ, Stanley EG, Elefanty AG, Sasai Y, Alvarez-Buylla A, Rubenstein JL, Kriegstein AR. Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development. Cell Stem Cell. 2013 May 02; 12(5):573-86.
  56. Wang B, Long JE, Flandin P, Pla R, Waclaw RR, Campbell K, Rubenstein JL. Loss of Gsx1 and Gsx2 function rescues distinct phenotypes in Dlx1/2 mutants. J Comp Neurol. 2013 May 01; 521(7):1561-84.
  57. Chen YJ, Vogt D, Wang Y, Visel A, Silberberg SN, Nicholas CR, Danjo T, Pollack JL, Pennacchio LA, Anderson S, Sasai Y, Baraban SC, Kriegstein AR, Alvarez-Buylla A, Rubenstein JL. Use of "MGE enhancers" for labeling and selection of embryonic stem cell-derived medial ganglionic eminence (MGE) progenitors and neurons. PLoS One. 2013; 8(5):e61956.
  58. Tabarés-Seisdedos R, Rubenstein JL. Inverse cancer comorbidity: a serendipitous opportunity to gain insight into CNS disorders. Nat Rev Neurosci. 2013 Apr; 14(4):293-304.
  59. Harrison-Uy SJ, Siegenthaler JA, Faedo A, Rubenstein JL, Pleasure SJ. CoupTFI interacts with retinoic acid signaling during cortical development. PLoS One. 2013; 8(3):e58219.
  60. DeFelipe J, López-Cruz PL, Benavides-Piccione R, Bielza C, Larrañaga P, Anderson S, Burkhalter A, Cauli B, Fairén A, Feldmeyer D, Fishell G, Fitzpatrick D, Freund TF, González-Burgos G, Hestrin S, Hill S, Hof PR, Huang J, Jones EG, Kawaguchi Y, Kisvárday Z, Kubota Y, Lewis DA, Marín O, Markram H, McBain CJ, Meyer HS, Monyer H, Nelson SB, Rockland K, Rossier J, Rubenstein JL, Rudy B, Scanziani M, Shepherd GM, Sherwood CC, Staiger JF, Tamás G, Thomson A, Wang Y, Yuste R, Ascoli GA. New insights into the classification and nomenclature of cortical GABAergic interneurons. Nat Rev Neurosci. 2013 03; 14(3):202-16.
  61. Cai Y, Zhang Q, Wang C, Zhang Y, Ma T, Zhou X, Tian M, Rubenstein JL, Yang Z. Nuclear receptor COUP-TFII-expressing neocortical interneurons are derived from the medial and lateral/caudal ganglionic eminence and define specific subsets of mature interneurons. J Comp Neurol. 2013 Feb 01; 521(2):479-97.
  62. Visel A, Taher L, Girgis H, May D, Golonzhka O, Hoch RV, McKinsey GL, Pattabiraman K, Silberberg SN, Blow MJ, Hansen DV, Nord AS, Akiyama JA, Holt A, Hosseini R, Phouanenavong S, Plajzer-Frick I, Shoukry M, Afzal V, Kaplan T, Kriegstein AR, Rubin EM, Ovcharenko I, Pennacchio LA, Rubenstein JL. A high-resolution enhancer atlas of the developing telencephalon. Cell. 2013 Feb 14; 152(4):895-908.
  63. Borello U, Madhavan M, Vilinsky I, Faedo A, Pierani A, Rubenstein J, Campbell K. Sp8 and COUP-TF1 reciprocally regulate patterning and Fgf signaling in cortical progenitors. Cereb Cortex. 2014 Jun; 24(6):1409-21.
  64. McKinsey GL, Lindtner S, Trzcinski B, Visel A, Pennacchio LA, Huylebroeck D, Higashi Y, Rubenstein JL. Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons. Neuron. 2013 Jan 09; 77(1):83-98.
  65. Southwell DG, Paredes MF, Galvao RP, Jones DL, Froemke RC, Sebe JY, Alfaro-Cervello C, Tang Y, Garcia-Verdugo JM, Rubenstein JL, Baraban SC, Alvarez-Buylla A. Intrinsically determined cell death of developing cortical interneurons. Nature. 2012 Nov 01; 491(7422):109-13.
  66. Jeong J, Cesario J, Zhao Y, Burns L, Westphal H, Rubenstein JL. Cleft palate defect of Dlx1/2-/- mutant mice is caused by lack of vertical outgrowth in the posterior palate. Dev Dyn. 2012 Nov; 241(11):1757-69.
  67. Li Y, Yui D, Luikart BW, McKay RM, Li Y, Rubenstein JL, Parada LF. Conditional ablation of brain-derived neurotrophic factor-TrkB signaling impairs striatal neuron development. Proc Natl Acad Sci U S A. 2012 Sep 18; 109(38):15491-6.
  68. Delogu A, Sellers K, Zagoraiou L, Bocianowska-Zbrog A, Mandal S, Guimera J, Rubenstein JL, Sugden D, Jessell T, Lumsden A. Subcortical visual shell nuclei targeted by ipRGCs develop from a Sox14+-GABAergic progenitor and require Sox14 to regulate daily activity rhythms. Neuron. 2012 Aug 23; 75(4):648-62.
  69. Han S, Tai C, Westenbroek RE, Yu FH, Cheah CS, Potter GB, Rubenstein JL, Scheuer T, de la Iglesia HO, Catterall WA. Autistic-like behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmission. Nature. 2012 Sep 20; 489(7416):385-90.
  70. Cheah CS, Yu FH, Westenbroek RE, Kalume FK, Oakley JC, Potter GB, Rubenstein JL, Catterall WA. Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome. Proc Natl Acad Sci U S A. 2012 Sep 04; 109(36):14646-51.
  71. Andrews-Zwilling Y, Gillespie AK, Kravitz AV, Nelson AB, Devidze N, Lo I, Yoon SY, Bien-Ly N, Ring K, Zwilling D, Potter GB, Rubenstein JL, Kreitzer AC, Huang Y. Hilar GABAergic interneuron activity controls spatial learning and memory retrieval. PLoS One. 2012; 7(7):e40555.
  72. Seybold BA, Stanco A, Cho KK, Potter GB, Kim C, Sohal VS, Rubenstein JL, Schreiner CE. Chronic reduction in inhibition reduces receptive field size in mouse auditory cortex. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13829-34.
  73. Bráz JM, Sharif-Naeini R, Vogt D, Kriegstein A, Alvarez-Buylla A, Rubenstein JL, Basbaum AI. Forebrain GABAergic neuron precursors integrate into adult spinal cord and reduce injury-induced neuropathic pain. Neuron. 2012 May 24; 74(4):663-75.
  74. Tang K, Rubenstein JL, Tsai SY, Tsai MJ. COUP-TFII controls amygdala patterning by regulating neuropilin expression. Development. 2012 May; 139(9):1630-9.
  75. Sanchez-Ortiz E, Yui D, Song D, Li Y, Rubenstein JL, Reichardt LF, Parada LF. TrkA gene ablation in basal forebrain results in dysfunction of the cholinergic circuitry. J Neurosci. 2012 Mar 21; 32(12):4065-79.
  76. Martín-Ibáñez R, Crespo E, Esgleas M, Urban N, Wang B, Waclaw R, Georgopoulos K, Martínez S, Campbell K, Vicario-Abejón C, Alberch J, Chan S, Kastner P, Rubenstein JL, Canals JM. Helios transcription factor expression depends on Gsx2 and Dlx1&2 function in developing striatal matrix neurons. Stem Cells Dev. 2012 Aug 10; 21(12):2239-51.
  77. Ma T, Zhang Q, Cai Y, You Y, Rubenstein JL, Yang Z. A subpopulation of dorsal lateral/caudal ganglionic eminence-derived neocortical interneurons expresses the transcription factor Sp8. Cereb Cortex. 2012 Sep; 22(9):2120-30.
  78. Wang B, Lufkin T, Rubenstein JL. Dlx6 regulates molecular properties of the striatum and central nucleus of the amygdala. J Comp Neurol. 2011 Aug 15; 519(12):2320-34.
  79. Mao R, Schummers J, Knoblich U, Lacey CJ, Van Wart A, Cobos I, Kim C, Huguenard JR, Rubenstein JL, Sur M. Influence of a subtype of inhibitory interneuron on stimulus-specific responses in visual cortex. Cereb Cortex. 2012 Mar; 22(3):493-508.
  80. Flandin P, Zhao Y, Vogt D, Jeong J, Long J, Potter G, Westphal H, Rubenstein JL. Lhx6 and Lhx8 coordinately induce neuronal expression of Shh that controls the generation of interneuron progenitors. Neuron. 2011 Jun 09; 70(5):939-50.
  81. Hansen DV, Rubenstein JL, Kriegstein AR. Deriving excitatory neurons of the neocortex from pluripotent stem cells. Neuron. 2011 May 26; 70(4):645-60.
  82. Tabarés-Seisdedos R, Dumont N, Baudot A, Valderas JM, Climent J, Valencia A, Crespo-Facorro B, Vieta E, Gómez-Beneyto M, Martínez S, Rubenstein JL. No paradox, no progress: inverse cancer comorbidity in people with other complex diseases. Lancet Oncol. 2011 Jun; 12(6):604-8.
  83. Jones DL, Howard MA, Stanco A, Rubenstein JL, Baraban SC. Deletion of Dlx1 results in reduced glutamatergic input to hippocampal interneurons. J Neurophysiol. 2011 May; 105(5):1984-91.
  84. Danjo T, Eiraku M, Muguruma K, Watanabe K, Kawada M, Yanagawa Y, Rubenstein JL, Sasai Y. Subregional specification of embryonic stem cell-derived ventral telencephalic tissues by timed and combinatory treatment with extrinsic signals. J Neurosci. 2011 Feb 02; 31(5):1919-33.
  85. Wang Y, Li G, Stanco A, Long JE, Crawford D, Potter GB, Pleasure SJ, Behrens T, Rubenstein JL. CXCR4 and CXCR7 have distinct functions in regulating interneuron migration. Neuron. 2011 Jan 13; 69(1):61-76.
  86. McKenna WL, Betancourt J, Larkin KA, Abrams B, Guo C, Rubenstein JL, Chen B. Tbr1 and Fezf2 regulate alternate corticofugal neuronal identities during neocortical development. J Neurosci. 2011 Jan 12; 31(2):549-64.
  87. Sajan SA, Rubenstein JL, Warchol ME, Lovett M. Identification of direct downstream targets of Dlx5 during early inner ear development. Hum Mol Genet. 2011 Apr 01; 20(7):1262-73.
  88. Lek M, Dias JM, Marklund U, Uhde CW, Kurdija S, Lei Q, Sussel L, Rubenstein JL, Matise MP, Arnold HH, Jessell TM, Ericson J. A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning. Development. 2010 Dec; 137(23):4051-60.
  89. Chao HT, Chen H, Samaco RC, Xue M, Chahrour M, Yoo J, Neul JL, Gong S, Lu HC, Heintz N, Ekker M, Rubenstein JL, Noebels JL, Rosenmund C, Zoghbi HY. Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. Nature. 2010 Nov 11; 468(7321):263-9.
  90. Rubenstein JL. Annual Research Review: Development of the cerebral cortex: implications for neurodevelopmental disorders. J Child Psychol Psychiatry. 2011 Apr; 52(4):339-55.
  91. Poitras L, Yu M, Lesage-Pelletier C, Macdonald RB, Gagné JP, Hatch G, Kelly I, Hamilton SP, Rubenstein JL, Poirier GG, Ekker M. An SNP in an ultraconserved regulatory element affects Dlx5/Dlx6 regulation in the forebrain. Development. 2010 Sep; 137(18):3089-97.
  92. Kaneko N, Marín O, Koike M, Hirota Y, Uchiyama Y, Wu JY, Lu Q, Tessier-Lavigne M, Alvarez-Buylla A, Okano H, Rubenstein JL, Sawamoto K. New neurons clear the path of astrocytic processes for their rapid migration in the adult brain. Neuron. 2010 Jul 29; 67(2):213-23.
  93. Bedogni F, Hodge RD, Elsen GE, Nelson BR, Daza RA, Beyer RP, Bammler TK, Rubenstein JL, Hevner RF. Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex. Proc Natl Acad Sci U S A. 2010 Jul 20; 107(29):13129-34.
  94. Wang Y, Dye CA, Sohal V, Long JE, Estrada RC, Roztocil T, Lufkin T, Deisseroth K, Baraban SC, Rubenstein JL. Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons. J Neurosci. 2010 Apr 14; 30(15):5334-45.
  95. Rubenstein JL. Three hypotheses for developmental defects that may underlie some forms of autism spectrum disorder. Curr Opin Neurol. 2010 Apr; 23(2):118-23.
  96. Moldrich RX, Pannek K, Hoch R, Rubenstein JL, Kurniawan ND, Richards LJ. Comparative mouse brain tractography of diffusion magnetic resonance imaging. Neuroimage. 2010 Jul 01; 51(3):1027-36.
  97. Faedo A, Borello U, Rubenstein JL. Repression of Fgf signaling by sprouty1-2 regulates cortical patterning in two distinct regions and times. J Neurosci. 2010 Mar 17; 30(11):4015-23.
  98. Maira M, Long JE, Lee AY, Rubenstein JL, Stifani S. Erratum to: Role for TGF-ß superfamily signaling in telencephalic GABAergic neuron development. J Neurodev Disord. 2010 Mar; 2(1):47.
  99. Flandin P, Kimura S, Rubenstein JL. The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons. J Neurosci. 2010 Feb 24; 30(8):2812-23.
  100. Martín-Ibáñez R, Crespo E, Urbán N, Sergent-Tanguy S, Herranz C, Jaumot M, Valiente M, Long JE, Pineda JR, Andreu C, Rubenstein JL, Marín O, Georgopoulos K, Mengod G, Fariñas I, Bachs O, Alberch J, Canals JM. Ikaros-1 couples cell cycle arrest of late striatal precursors with neurogenesis of enkephalinergic neurons. J Comp Neurol. 2010 Feb 01; 518(3):329-51.
  101. Endoh-Yamagami S, Karkar KM, May SR, Cobos I, Thwin MT, Long JE, Ashique AM, Zarbalis K, Rubenstein JL, Peterson AS. A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice. Dev Biol. 2010 Apr 01; 340(1):41-53.
  102. Han J, Mayo J, Xu X, Li J, Bringas P, Maas RL, Rubenstein JL, Chai Y. Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice. Development. 2009 Dec; 136(24):4225-33.
  103. Maira M, Long JE, Lee AY, Rubenstein JL, Stifani S. Role for TGF-beta superfamily signaling in telencephalic GABAergic neuron development. J Neurodev Disord. 2010 Mar; 2(1):48-60.
  104. Yee CL, Wang Y, Anderson S, Ekker M, Rubenstein JL. Arcuate nucleus expression of NKX2.1 and DLX and lineages expressing these transcription factors in neuropeptide Y(+), proopiomelanocortin(+), and tyrosine hydroxylase(+) neurons in neonatal and adult mice. J Comp Neurol. 2009 Nov 01; 517(1):37-50.
  105. Baraban SC, Southwell DG, Estrada RC, Jones DL, Sebe JY, Alfaro-Cervello C, García-Verdugo JM, Rubenstein JL, Alvarez-Buylla A. Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant mice. Proc Natl Acad Sci U S A. 2009 Sep 08; 106(36):15472-7.
  106. Winden KD, Oldham MC, Mirnics K, Ebert PJ, Swan CH, Levitt P, Rubenstein JL, Horvath S, Geschwind DH. The organization of the transcriptional network in specific neuronal classes. Mol Syst Biol. 2009; 5:291.
  107. Mao R, Page DT, Merzlyak I, Kim C, Tecott LH, Janak PH, Rubenstein JL, Sur M. Reduced conditioned fear response in mice that lack Dlx1 and show subtype-specific loss of interneurons. J Neurodev Disord. 2009 Sep; 1(3):224-36.
  108. Sansom SN, Griffiths DS, Faedo A, Kleinjan DJ, Ruan Y, Smith J, van Heyningen V, Rubenstein JL, Livesey FJ. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet. 2009 Jun; 5(6):e1000511.
  109. Long JE, Cobos I, Potter GB, Rubenstein JL. Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways. Cereb Cortex. 2009 Jul; 19 Suppl 1:i96-106.
  110. Hoch RV, Rubenstein JL, Pleasure S. Genes and signaling events that establish regional patterning of the mammalian forebrain. Semin Cell Dev Biol. 2009 Jun; 20(4):378-86.
  111. Long JE, Swan C, Liang WS, Cobos I, Potter GB, Rubenstein JL. Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways. J Comp Neurol. 2009 Feb 01; 512(4):556-72.
  112. Potter GB, Petryniak MA, Shevchenko E, McKinsey GL, Ekker M, Rubenstein JL. Generation of Cre-transgenic mice using Dlx1/Dlx2 enhancers and their characterization in GABAergic interneurons. Mol Cell Neurosci. 2009 Feb; 40(2):167-86.
  113. Walsh CA, Morrow EM, Rubenstein JL. Autism and brain development. Cell. 2008 Oct 31; 135(3):396-400.
  114. Colasante G, Collombat P, Raimondi V, Bonanomi D, Ferrai C, Maira M, Yoshikawa K, Mansouri A, Valtorta F, Rubenstein JL, Broccoli V. Arx is a direct target of Dlx2 and thereby contributes to the tangential migration of GABAergic interneurons. J Neurosci. 2008 Oct 15; 28(42):10674-86.
  115. Zhao Y, Flandin P, Long JE, Cuesta MD, Westphal H, Rubenstein JL. Distinct molecular pathways for development of telencephalic interneuron subtypes revealed through analysis of Lhx6 mutants. J Comp Neurol. 2008 Sep 01; 510(1):79-99.
  116. Jeong J, Li X, McEvilly RJ, Rosenfeld MG, Lufkin T, Rubenstein JL. Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs. Development. 2008 Sep; 135(17):2905-16.
  117. Ohtsuka N, Tansky MF, Kuang H, Kourrich S, Thomas MJ, Rubenstein JL, Ekker M, Leeman SE, Tsien JZ. Functional disturbances in the striatum by region-specific ablation of NMDA receptors. Proc Natl Acad Sci U S A. 2008 Sep 02; 105(35):12961-6.
  118. Ghanem N, Yu M, Poitras L, Rubenstein JL, Ekker M. Characterization of a distinct subpopulation of striatal projection neurons expressing the Dlx genes in the basal ganglia through the activity of the I56ii enhancer. Dev Biol. 2008 Oct 15; 322(2):415-24.
  119. Sunwoo JB, Kim S, Yang L, Naik T, Higuchi DA, Rubenstein JL, Yokoyama WM. Distal-less homeobox transcription factors regulate development and maturation of natural killer cells. Proc Natl Acad Sci U S A. 2008 Aug 05; 105(31):10877-82.
  120. Borello U, Cobos I, Long JE, McWhirter JR, Murre C, Rubenstein JL. FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development. Neural Dev. 2008 Jul 14; 3:17.
  121. Cholfin JA, Rubenstein JL. Frontal cortex subdivision patterning is coordinately regulated by Fgf8, Fgf17, and Emx2. J Comp Neurol. 2008 Jul 10; 509(2):144-55.
  122. Vasudevan A, Long JE, Crandall JE, Rubenstein JL, Bhide PG. Compartment-specific transcription factors orchestrate angiogenesis gradients in the embryonic brain. Nat Neurosci. 2008 Apr; 11(4):429-39.
  123. Li G, Adesnik H, Li J, Long J, Nicoll RA, Rubenstein JL, Pleasure SJ. Regional distribution of cortical interneurons and development of inhibitory tone are regulated by Cxcl12/Cxcr4 signaling. J Neurosci. 2008 Jan 30; 28(5):1085-98.
  124. García-López M, Abellán A, Legaz I, Rubenstein JL, Puelles L, Medina L. Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development. J Comp Neurol. 2008 Jan 01; 506(1):46-74.
  125. Faedo A, Tomassy GS, Ruan Y, Teichmann H, Krauss S, Pleasure SJ, Tsai SY, Tsai MJ, Studer M, Rubenstein JL. COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling. Cereb Cortex. 2008 Sep; 18(9):2117-31.
  126. Bardet SM, Martinez-de-la-Torre M, Northcutt RG, Rubenstein JL, Puelles L. Conserved pattern of OTP-positive cells in the paraventricular nucleus and other hypothalamic sites of tetrapods. Brain Res Bull. 2008 Mar 18; 75(2-4):231-5.
  127. Scearce-Levie K, Roberson ED, Gerstein H, Cholfin JA, Mandiyan VS, Shah NM, Rubenstein JL, Mucke L. Abnormal social behaviors in mice lacking Fgf17. Genes Brain Behav. 2008 Apr; 7(3):344-54.
  128. Flames N, Pla R, Gelman DM, Rubenstein JL, Puelles L, Marín O. Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes. J Neurosci. 2007 Sep 05; 27(36):9682-95.
  129. Petryniak MA, Potter GB, Rowitch DH, Rubenstein JL. Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrain. Neuron. 2007 Aug 02; 55(3):417-33.
  130. Kohwi M, Petryniak MA, Long JE, Ekker M, Obata K, Yanagawa Y, Rubenstein JL, Alvarez-Buylla A. A subpopulation of olfactory bulb GABAergic interneurons is derived from Emx1- and Dlx5/6-expressing progenitors. J Neurosci. 2007 Jun 27; 27(26):6878-91.
  131. Cobos I, Borello U, Rubenstein JL. Dlx transcription factors promote migration through repression of axon and dendrite growth. Neuron. 2007 Jun 21; 54(6):873-88.
  132. Ghanem N, Yu M, Long J, Hatch G, Rubenstein JL, Ekker M. Distinct cis-regulatory elements from the Dlx1/Dlx2 locus mark different progenitor cell populations in the ganglionic eminences and different subtypes of adult cortical interneurons. J Neurosci. 2007 May 09; 27(19):5012-22.
  133. Colombo E, Collombat P, Colasante G, Bianchi M, Long J, Mansouri A, Rubenstein JL, Broccoli V. Inactivation of Arx, the murine ortholog of the X-linked lissencephaly with ambiguous genitalia gene, leads to severe disorganization of the ventral telencephalon with impaired neuronal migration and differentiation. J Neurosci. 2007 Apr 25; 27(17):4786-98.
  134. Cholfin JA, Rubenstein JL. Patterning of frontal cortex subdivisions by Fgf17. Proc Natl Acad Sci U S A. 2007 May 01; 104(18):7652-7.
  135. Long JE, Garel S, Alvarez-Dolado M, Yoshikawa K, Osumi N, Alvarez-Buylla A, Rubenstein JL. Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiation. J Neurosci. 2007 Mar 21; 27(12):3230-43.
  136. Cholfin JA, Rubenstein JL. Genetic regulation of prefrontal cortex development and function. Novartis Found Symp. 2007; 288:165-73; discussion 173-7, 276-81.
  137. Edmonds L, Liu A, Kwan JJ, Avanessy A, Caracoglia M, Yang I, Maxwell KL, Rubenstein J, Davidson AR, Donaldson LW. The NMR structure of the gpU tail-terminator protein from bacteriophage lambda: identification of sites contributing to Mg(II)-mediated oligomerization and biological function. J Mol Biol. 2007 Jan 05; 365(1):175-86.
  138. Zhou CJ, Borello U, Rubenstein JL, Pleasure SJ. Neuronal production and precursor proliferation defects in the neocortex of mice with loss of function in the canonical Wnt signaling pathway. Neuroscience. 2006 Nov 03; 142(4):1119-31.
  139. Monory K, Massa F, Egertová M, Eder M, Blaudzun H, Westenbroek R, Kelsch W, Jacob W, Marsch R, Ekker M, Long J, Rubenstein JL, Goebbels S, Nave KA, During M, Klugmann M, Wölfel B, Dodt HU, Zieglgänsberger W, Wotjak CT, Mackie K, Elphick MR, Marsicano G, Lutz B. The endocannabinoid system controls key epileptogenic circuits in the hippocampus. Neuron. 2006 Aug 17; 51(4):455-66.
  140. Alvarez-Dolado M, Calcagnotto ME, Karkar KM, Southwell DG, Jones-Davis DM, Estrada RC, Rubenstein JL, Alvarez-Buylla A, Baraban SC. Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain. J Neurosci. 2006 Jul 12; 26(28):7380-9.
  141. Cobos I, Long JE, Thwin MT, Rubenstein JL. Cellular patterns of transcription factor expression in developing cortical interneurons. Cereb Cortex. 2006 Jul; 16 Suppl 1:i82-8.
  142. Moldin SO, Rubenstein JL, Hyman SE. Can autism speak to neuroscience? J Neurosci. 2006 Jun 28; 26(26):6893-6.
  143. Storm EE, Garel S, Borello U, Hebert JM, Martinez S, McConnell SK, Martin GR, Rubenstein JL. Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers. Development. 2006 May; 133(9):1831-44.
  144. Polley DB, Cobos I, Merzenich MM, Rubenstein JL. Severe hearing loss in Dlxl mutant mice. Hear Res. 2006 Apr; 214(1-2):84-8.
  145. Sawamoto K, Wichterle H, Gonzalez-Perez O, Cholfin JA, Yamada M, Spassky N, Murcia NS, Garcia-Verdugo JM, Marin O, Rubenstein JL, Tessier-Lavigne M, Okano H, Alvarez-Buylla A. New neurons follow the flow of cerebrospinal fluid in the adult brain. Science. 2006 Feb 03; 311(5761):629-32.
  146. Sur M, Rubenstein JL. Patterning and plasticity of the cerebral cortex. Science. 2005 Nov 04; 310(5749):805-10.
  147. Hamilton SP, Woo JM, Carlson EJ, Ghanem N, Ekker M, Rubenstein JL. Analysis of four DLX homeobox genes in autistic probands. BMC Genet. 2005 Nov 02; 6:52.
  148. Depew MJ, Simpson CA, Morasso M, Rubenstein JL. Reassessing the Dlx code: the genetic regulation of branchial arch skeletal pattern and development. J Anat. 2005 Nov; 207(5):501-61.
  149. Bulfone A, Carotenuto P, Faedo A, Aglio V, Garzia L, Bello AM, Basile A, Andrè A, Cocchia M, Guardiola O, Ballabio A, Rubenstein JL, Zollo M. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. J Neurosci. 2005 Aug 17; 25(33):7586-600.
  150. Kohwi M, Osumi N, Rubenstein JL, Alvarez-Buylla A. Pax6 is required for making specific subpopulations of granule and periglomerular neurons in the olfactory bulb. J Neurosci. 2005 Jul 27; 25(30):6997-7003.
  151. Cobos I, Calcagnotto ME, Vilaythong AJ, Thwin MT, Noebels JL, Baraban SC, Rubenstein JL. Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy. Nat Neurosci. 2005 Aug; 8(8):1059-68.
  152. Cobos I, Broccoli V, Rubenstein JL. The vertebrate ortholog of Aristaless is regulated by Dlx genes in the developing forebrain. J Comp Neurol. 2005 Mar 14; 483(3):292-303.
  153. Studer M, Filosa A, Rubenstein JL. The nuclear receptor COUP-TFI represses differentiation of Cajal-Retzius cells. Brain Res Bull. 2005 Sep 15; 66(4-6):394-401.
  154. Givens ML, Rave-Harel N, Goonewardena VD, Kurotani R, Berdy SE, Swan CH, Rubenstein JL, Robert B, Mellon PL. Developmental regulation of gonadotropin-releasing hormone gene expression by the MSX and DLX homeodomain protein families. J Biol Chem. 2005 May 13; 280(19):19156-65.
  155. de Melo J, Du G, Fonseca M, Gillespie LA, Turk WJ, Rubenstein JL, Eisenstat DD. Dlx1 and Dlx2 function is necessary for terminal differentiation and survival of late-born retinal ganglion cells in the developing mouse retina. Development. 2005 Jan; 132(2):311-22.
  156. Wang TF, Ding CN, Wang GS, Luo SC, Lin YL, Ruan Y, Hevner R, Rubenstein JL, Hsueh YP. Identification of Tbr-1/CASK complex target genes in neurons. J Neurochem. 2004 Dec; 91(6):1483-92.
  157. Faedo A, Quinn JC, Stoney P, Long JE, Dye C, Zollo M, Rubenstein JL, Price DJ, Bulfone A. Identification and characterization of a novel transcript down-regulated in Dlx1/Dlx2 and up-regulated in Pax6 mutant telencephalon. Dev Dyn. 2004 Nov; 231(3):614-20.
  158. Flames N, Long JE, Garratt AN, Fischer TM, Gassmann M, Birchmeier C, Lai C, Rubenstein JL, Marín O. Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1. Neuron. 2004 Oct 14; 44(2):251-61.
  159. Huffman KJ, Garel S, Rubenstein JL. Fgf8 regulates the development of intra-neocortical projections. J Neurosci. 2004 Oct 13; 24(41):8917-23.
  160. Yun K, Mantani A, Garel S, Rubenstein J, Israel MA. Id4 regulates neural progenitor proliferation and differentiation in vivo. Development. 2004 Nov; 131(21):5441-8.
  161. Jones EG, Rubenstein JL. Expression of regulatory genes during differentiation of thalamic nuclei in mouse and monkey. J Comp Neurol. 2004 Sep 06; 477(1):55-80.
  162. Garel S, Rubenstein JL. Intermediate targets in formation of topographic projections: inputs from the thalamocortical system. Trends Neurosci. 2004 Sep; 27(9):533-9.
  163. Zarbalis K, May SR, Shen Y, Ekker M, Rubenstein JL, Peterson AS. A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development. PLoS Biol. 2004 Aug; 2(8):E219.
  164. Medina L, Legaz I, González G, De Castro F, Rubenstein JL, Puelles L. Expression of Dbx1, Neurogenin 2, Semaphorin 5A, Cadherin 8, and Emx1 distinguish ventral and lateral pallial histogenetic divisions in the developing mouse claustroamygdaloid complex. J Comp Neurol. 2004 Jul 05; 474(4):504-23.
  165. Pan Q, Li C, Xiao J, Kimura S, Rubenstein J, Puelles L, Minoo P. In vivo characterization of the Nkx2.1 promoter/enhancer elements in transgenic mice. Gene. 2004 Apr 28; 331:73-82.
  166. Xu Q, Cobos I, De La Cruz E, Rubenstein JL, Anderson SA. Origins of cortical interneuron subtypes. J Neurosci. 2004 Mar 17; 24(11):2612-22.
  167. Liu R, Cai J, Hu X, Tan M, Qi Y, German M, Rubenstein J, Sander M, Qiu M. Region-specific and stage-dependent regulation of Olig gene expression and oligodendrogenesis by Nkx6.1 homeodomain transcription factor. Development. 2003 Dec; 130(25):6221-31.
  168. Blackshear PJ, Graves JP, Stumpo DJ, Cobos I, Rubenstein JL, Zeldin DC. Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4. Development. 2003 Oct; 130(19):4539-52.
  169. Rubenstein JL, Merzenich MM. Model of autism: increased ratio of excitation/inhibition in key neural systems. Genes Brain Behav. 2003 Oct; 2(5):255-67.
  170. Puelles L, Rubenstein JL. Forebrain gene expression domains and the evolving prosomeric model. Trends Neurosci. 2003 Sep; 26(9):469-76.
  171. Zhao Y, Marín O, Hermesz E, Powell A, Flames N, Palkovits M, Rubenstein JL, Westphal H. The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain. Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):9005-10.
  172. Yun K, Garel S, Fischman S, Rubenstein JL. Patterning of the lateral ganglionic eminence by the Gsh1 and Gsh2 homeobox genes regulates striatal and olfactory bulb histogenesis and the growth of axons through the basal ganglia. J Comp Neurol. 2003 Jun 23; 461(2):151-65.
  173. Garel S, Huffman KJ, Rubenstein JL. Molecular regionalization of the neocortex is disrupted in Fgf8 hypomorphic mutants. Development. 2003 May; 130(9):1903-14.
  174. Andrews GL, Yun K, Rubenstein JL, Mastick GS. Dlx transcription factors regulate differentiation of dopaminergic neurons of the ventral thalamus. Mol Cell Neurosci. 2003 May; 23(1):107-20.
  175. Marín O, Plump AS, Flames N, Sánchez-Camacho C, Tessier-Lavigne M, Rubenstein JL. Directional guidance of interneuron migration to the cerebral cortex relies on subcortical Slit1/2-independent repulsion and cortical attraction. Development. 2003 May; 130(9):1889-901.
  176. Ghanem N, Jarinova O, Amores A, Long Q, Hatch G, Park BK, Rubenstein JL, Ekker M. Regulatory roles of conserved intergenic domains in vertebrate Dlx bigene clusters. Genome Res. 2003 Apr; 13(4):533-43.
  177. Bishop KM, Garel S, Nakagawa Y, Rubenstein JL, O'Leary DD. Emx1 and Emx2 cooperate to regulate cortical size, lamination, neuronal differentiation, development of cortical efferents, and thalamocortical pathfinding. J Comp Neurol. 2003 Mar 17; 457(4):345-60.
  178. Hevner RF, Daza RA, Rubenstein JL, Stunnenberg H, Olavarria JF, Englund C. Beyond laminar fate: toward a molecular classification of cortical projection/pyramidal neurons. Dev Neurosci. 2003 Mar-Aug; 25(2-4):139-51.
  179. Marín O, Rubenstein JL. Cell migration in the forebrain. Annu Rev Neurosci. 2003; 26:441-83.
  180. Storm EE, Rubenstein JL, Martin GR. Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain. Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1757-62.
  181. Long JE, Garel S, Depew MJ, Tobet S, Rubenstein JL. DLX5 regulates development of peripheral and central components of the olfactory system. J Neurosci. 2003 Jan 15; 23(2):568-78.
  182. Garel S, Yun K, Grosschedl R, Rubenstein JL. The early topography of thalamocortical projections is shifted in Ebf1 and Dlx1/2 mutant mice. Development. 2002 Dec; 129(24):5621-34.
  183. Yun K, Fischman S, Johnson J, Hrabe de Angelis M, Weinmaster G, Rubenstein JL. Modulation of the notch signaling by Mash1 and Dlx1/2 regulates sequential specification and differentiation of progenitor cell types in the subcortical telencephalon. Development. 2002 Nov; 129(21):5029-40.
  184. Panganiban G, Rubenstein JL. Developmental functions of the Distal-less/Dlx homeobox genes. Development. 2002 Oct; 129(19):4371-86.
  185. Bishop KM, Rubenstein JL, O'Leary DD. Distinct actions of Emx1, Emx2, and Pax6 in regulating the specification of areas in the developing neocortex. J Neurosci. 2002 Sep 01; 22(17):7627-38.
  186. Depew MJ, Lufkin T, Rubenstein JL. Specification of jaw subdivisions by Dlx genes. Science. 2002 Oct 11; 298(5592):381-5.
  187. Gorski JA, Talley T, Qiu M, Puelles L, Rubenstein JL, Jones KR. Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage. J Neurosci. 2002 Aug 01; 22(15):6309-14.
  188. Faedo A, Ficara F, Ghiani M, Aiuti A, Rubenstein JL, Bulfone A. Developmental expression of the T-box transcription factor T-bet/Tbx21 during mouse embryogenesis. Mech Dev. 2002 Aug; 116(1-2):157-60.
  189. Anderson SA, Kaznowski CE, Horn C, Rubenstein JL, McConnell SK. Distinct origins of neocortical projection neurons and interneurons in vivo. Cereb Cortex. 2002 Jul; 12(7):702-9.
  190. Hevner RF, Miyashita-Lin E, Rubenstein JL. Cortical and thalamic axon pathfinding defects in Tbr1, Gbx2, and Pax6 mutant mice: evidence that cortical and thalamic axons interact and guide each other. J Comp Neurol. 2002 May 20; 447(1):8-17.
  191. Marín O, Baker J, Puelles L, Rubenstein JL. Patterning of the basal telencephalon and hypothalamus is essential for guidance of cortical projections. Development. 2002 Feb; 129(3):761-73.
  192. Bagri A, Marín O, Plump AS, Mak J, Pleasure SJ, Rubenstein JL, Tessier-Lavigne M. Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain. Neuron. 2002 Jan 17; 33(2):233-48.
  193. Ohkubo Y, Chiang C, Rubenstein JL. Coordinate regulation and synergistic actions of BMP4, SHH and FGF8 in the rostral prosencephalon regulate morphogenesis of the telencephalic and optic vesicles. Neuroscience. 2002; 111(1):1-17.
  194. Stühmer T, Puelles L, Ekker M, Rubenstein JL. Expression from a Dlx gene enhancer marks adult mouse cortical GABAergic neurons. Cereb Cortex. 2002 Jan; 12(1):75-85.
  195. Stühmer T, Anderson SA, Ekker M, Rubenstein JL. Ectopic expression of the Dlx genes induces glutamic acid decarboxylase and Dlx expression. Development. 2002 Jan; 129(1):245-52.
  196. Garda AL, Puelles L, Rubenstein JL, Medina L. Expression patterns of Wnt8b and Wnt7b in the chicken embryonic brain suggest a correlation with forebrain patterning centers and morphogenesis. Neuroscience. 2002; 113(3):689-98.
  197. Cobos I, Shimamura K, Rubenstein JL, Martínez S, Puelles L. Fate map of the avian anterior forebrain at the four-somite stage, based on the analysis of quail-chick chimeras. Dev Biol. 2001 Nov 01; 239(1):46-67.
  198. Marín O, Rubenstein JL. A long, remarkable journey: tangential migration in the telencephalon. Nat Rev Neurosci. 2001 Nov; 2(11):780-90.
  199. Yu G, Zerucha T, Ekker M, Rubenstein JL. Evidence that GRIP, a PDZ-domain protein which is expressed in the embryonic forebrain, co-activates transcription with DLX homeodomain proteins. Brain Res Dev Brain Res. 2001 Oct 24; 130(2):217-30.
  200. Selleri L, Depew MJ, Jacobs Y, Chanda SK, Tsang KY, Cheah KS, Rubenstein JL, O'Gorman S, Cleary ML. Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation. Development. 2001 Sep; 128(18):3543-57.
  201. Pham TA, Rubenstein JL, Silva AJ, Storm DR, Stryker MP. The CRE/CREB pathway is transiently expressed in thalamic circuit development and contributes to refinement of retinogeniculate axons. Neuron. 2001 Aug 16; 31(3):409-20.
  202. Marín O, Yaron A, Bagri A, Tessier-Lavigne M, Rubenstein JL. Sorting of striatal and cortical interneurons regulated by semaphorin-neuropilin interactions. Science. 2001 Aug 03; 293(5531):872-5.
  203. Qi Y, Cai J, Wu Y, Wu R, Lee J, Fu H, Rao M, Sussel L, Rubenstein J, Qiu M. Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor. Development. 2001 Jul; 128(14):2723-33.
  204. Schneider RA, Hu D, Rubenstein JL, Maden M, Helms JA. Local retinoid signaling coordinates forebrain and facial morphogenesis by maintaining FGF8 and SHH. Development. 2001 Jul; 128(14):2755-67.
  205. Xu SC, Harris MA, Rubenstein JL, Mundy GR, Harris SE. Bone morphogenetic protein-2 (BMP-2) signaling to the Col2alpha1 gene in chondroblasts requires the homeobox gene Dlx-2. DNA Cell Biol. 2001 Jun; 20(6):359-65.
  206. Puelles E, Rubenstein JL, Puelles L. Chicken Nkx6.1 expression at advanced stages of development identifies distinct brain nuclei derived from the basal plate. Mech Dev. 2001 Apr; 102(1-2):279-82.
  207. Kim AS, Anderson SA, Rubenstein JL, Lowenstein DH, Pleasure SJ. Pax-6 regulates expression of SFRP-2 and Wnt-7b in the developing CNS. J Neurosci. 2001 Mar 01; 21(5):RC132.
  208. Anderson SA, Marín O, Horn C, Jennings K, Rubenstein JL. Distinct cortical migrations from the medial and lateral ganglionic eminences. Development. 2001 Feb; 128(3):353-63.
  209. Hevner RF, Shi L, Justice N, Hsueh Y, Sheng M, Smiga S, Bulfone A, Goffinet AM, Campagnoni AT, Rubenstein JL. Tbr1 regulates differentiation of the preplate and layer 6. Neuron. 2001 Feb; 29(2):353-66.
  210. Yun K, Potter S, Rubenstein JL. Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon. Development. 2001 Jan; 128(2):193-205.
  211. Crossley PH, Martinez S, Ohkubo Y, Rubenstein JL. Coordinate expression of Fgf8, Otx2, Bmp4, and Shh in the rostral prosencephalon during development of the telencephalic and optic vesicles. Neuroscience. 2001; 108(2):183-206.
  212. Wilson SW, Rubenstein JL. Induction and dorsoventral patterning of the telencephalon. Neuron. 2000 Dec; 28(3):641-51.
  213. Pleasure SJ, Anderson S, Hevner R, Bagri A, Marin O, Lowenstein DH, Rubenstein JL. Cell migration from the ganglionic eminences is required for the development of hippocampal GABAergic interneurons. Neuron. 2000 Dec; 28(3):727-40.
  214. Sander M, Paydar S, Ericson J, Briscoe J, Berber E, German M, Jessell TM, Rubenstein JL. Ventral neural patterning by Nkx homeobox genes: Nkx6.1 controls somatic motor neuron and ventral interneuron fates. Genes Dev. 2000 Sep 01; 14(17):2134-9.
  215. Puelles L, Kuwana E, Puelles E, Bulfone A, Shimamura K, Keleher J, Smiga S, Rubenstein JL. Pallial and subpallial derivatives in the embryonic chick and mouse telencephalon, traced by the expression of the genes Dlx-2, Emx-1, Nkx-2.1, Pax-6, and Tbr-1. J Comp Neurol. 2000 Aug 28; 424(3):409-38.
  216. Marin O, Anderson SA, Rubenstein JL. Origin and molecular specification of striatal interneurons. J Neurosci. 2000 Aug 15; 20(16):6063-76.
  217. Galceran J, Miyashita-Lin EM, Devaney E, Rubenstein JL, Grosschedl R. Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1. Development. 2000 Feb; 127(3):469-82.
  218. Zerucha T, Stühmer T, Hatch G, Park BK, Long Q, Yu G, Gambarotta A, Schultz JR, Rubenstein JL, Ekker M. A highly conserved enhancer in the Dlx5/Dlx6 intergenic region is the site of cross-regulatory interactions between Dlx genes in the embryonic forebrain. J Neurosci. 2000 Jan 15; 20(2):709-21.
  219. Parnavelas JG, Anderson SA, Lavdas AA, Grigoriou M, Pachnis V, Rubenstein JL. The contribution of the ganglionic eminence to the neuronal cell types of the cerebral cortex. Novartis Found Symp. 2000; 228:129-39; discussion 139-47.
  220. Thomas BL, Liu JK, Rubenstein JL, Sharpe PT. Independent regulation of Dlx2 expression in the epithelium and mesenchyme of the first branchial arch. Development. 2000 Jan; 127(2):217-24.
  221. Rubenstein JL. Intrinsic and extrinsic control of cortical development. Novartis Found Symp. 2000; 228:67-75; discussion 75-82, 109-13.
  222. Trumpp A, Depew MJ, Rubenstein JL, Bishop JM, Martin GR. Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Genes Dev. 1999 Dec 01; 13(23):3136-48.
  223. Eisenstat DD, Liu JK, Mione M, Zhong W, Yu G, Anderson SA, Ghattas I, Puelles L, Rubenstein JL. DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal forebrain differentiation. J Comp Neurol. 1999 Nov 15; 414(2):217-37.
  224. Rubenstein JL, Anderson S, Shi L, Miyashita-Lin E, Bulfone A, Hevner R. Genetic control of cortical regionalization and connectivity. Cereb Cortex. 1999 Sep; 9(6):524-32.
  225. Anderson S, Mione M, Yun K, Rubenstein JL. Differential origins of neocortical projection and local circuit neurons: role of Dlx genes in neocortical interneuronogenesis. Cereb Cortex. 1999 Sep; 9(6):646-54.
  226. Rubenstein JL, Rakic P. Genetic control of cortical development. Cereb Cortex. 1999 Sep; 9(6):521-3.
  227. Depew MJ, Liu JK, Long JE, Presley R, Meneses JJ, Pedersen RA, Rubenstein JL. Dlx5 regulates regional development of the branchial arches and sensory capsules. Development. 1999 Sep; 126(17):3831-46.
  228. Miyashita-Lin EM, Hevner R, Wassarman KM, Martinez S, Rubenstein JL. Early neocortical regionalization in the absence of thalamic innervation. Science. 1999 Aug 06; 285(5429):906-9.
  229. Sussel L, Marin O, Kimura S, Rubenstein JL. Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum. Development. 1999 Aug; 126(15):3359-70.
  230. Bulfone A, Martinez S, Marigo V, Campanella M, Basile A, Quaderi N, Gattuso C, Rubenstein JL, Ballabio A. Expression pattern of the Tbr2 (Eomesodermin) gene during mouse and chick brain development. Mech Dev. 1999 Jun; 84(1-2):133-8.
  231. Briscoe J, Sussel L, Serup P, Hartigan-O'Connor D, Jessell TM, Rubenstein JL, Ericson J. Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling. Nature. 1999 Apr 15; 398(6728):622-7.
  232. Puelles L, Kuwana E, Puelles E, Rubenstein JL. Comparison of the mammalian and avian telencephalon from the perspective of gene expression data. Eur J Morphol. 1999 Apr; 37(2-3):139-50.
  233. Timpe LC, Jin KL, Puelles L, Rubenstein JL. Cyclic nucleotide-gated cation channel expression in embryonic chick brain. Brain Res Mol Brain Res. 1999 Mar 20; 66(1-2):175-8.
  234. Golden JA, Bracilovic A, McFadden KA, Beesley JS, Rubenstein JL, Grinspan JB. Ectopic bone morphogenetic proteins 5 and 4 in the chicken forebrain lead to cyclopia and holoprosencephaly. Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):2439-44.
  235. Martinez S, Crossley PH, Cobos I, Rubenstein JL, Martin GR. FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression. Development. 1999 Mar; 126(6):1189-200.
  236. Begbie J, Brunet JF, Rubenstein JL, Graham A. Induction of the epibranchial placodes. Development. 1999 Feb; 126(5):895-902.
  237. Marcus RC, Shimamura K, Sretavan D, Lai E, Rubenstein JL, Mason CA. Domains of regulatory gene expression and the developing optic chiasm: correspondence with retinal axon paths and candidate signaling cells. J Comp Neurol. 1999 Jan 18; 403(3):346-58.
  238. Bulfone A, Wang F, Hevner R, Anderson S, Cutforth T, Chen S, Meneses J, Pedersen R, Axel R, Rubenstein JL. An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons. Neuron. 1998 Dec; 21(6):1273-82.
  239. Rubenstein JL. Development of serotonergic neurons and their projections. Biol Psychiatry. 1998 Aug 01; 44(3):145-50.
  240. Lidral AC, Romitti PA, Basart AM, Doetschman T, Leysens NJ, Daack-Hirsch S, Semina EV, Johnson LR, Machida J, Burds A, Parnell TJ, Rubenstein JL, Murray JC. Association of MSX1 and TGFB3 with nonsyndromic clefting in humans. Am J Hum Genet. 1998 Aug; 63(2):557-68.
  241. Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA, Rubenstein JL, German MS. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development. 1998 Jun; 125(12):2213-21.
  242. Ye W, Shimamura K, Rubenstein JL, Hynes MA, Rosenthal A. FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Cell. 1998 May 29; 93(5):755-66.
  243. Rubenstein JL. Development of the cerebral cortex: V. Transcription factors and brain development. J Am Acad Child Adolesc Psychiatry. 1998 May; 37(5):561-2.
  244. Qiu M, Shimamura K, Sussel L, Chen S, Rubenstein JL. Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS development. Mech Dev. 1998 Mar; 72(1-2):77-88.
  245. Rubenstein JL, Beachy PA. Patterning of the embryonic forebrain. Curr Opin Neurobiol. 1998 Feb; 8(1):18-26.
  246. Thomas BL, Tucker AS, Ferguson C, Qiu M, Rubenstein JL, Sharpe PT. Molecular control of odontogenic patterning: positional dependent initiation and morphogenesis. Eur J Oral Sci. 1998 Jan; 106 Suppl 1:44-7.
  247. Rubenstein JL, Shimamura K, Martinez S, Puelles L. Regionalization of the prosencephalic neural plate. Annu Rev Neurosci. 1998; 21:445-77.
  248. Thomas BL, Tucker AS, Qui M, Ferguson CA, Hardcastle Z, Rubenstein JL, Sharpe PT. Role of Dlx-1 and Dlx-2 genes in patterning of the murine dentition. Development. 1997 Dec; 124(23):4811-8.
  249. Liu JK, Ghattas I, Liu S, Chen S, Rubenstein JL. Dlx genes encode DNA-binding proteins that are expressed in an overlapping and sequential pattern during basal ganglia differentiation. Dev Dyn. 1997 Dec; 210(4):498-512.
  250. Anderson SA, Eisenstat DD, Shi L, Rubenstein JL. Interneuron migration from basal forebrain to neocortex: dependence on Dlx genes. Science. 1997 Oct 17; 278(5337):474-6.
  251. Wassarman KM, Lewandoski M, Campbell K, Joyner AL, Rubenstein JL, Martinez S, Martin GR. Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function. Development. 1997 Aug; 124(15):2923-34.
  252. Shimamura K, Rubenstein JL. Inductive interactions direct early regionalization of the mouse forebrain. Development. 1997 Jul; 124(14):2709-18.
  253. Anderson SA, Qiu M, Bulfone A, Eisenstat DD, Meneses J, Pedersen R, Rubenstein JL. Mutations of the homeobox genes Dlx-1 and Dlx-2 disrupt the striatal subventricular zone and differentiation of late born striatal neurons. Neuron. 1997 Jul; 19(1):27-37.
  254. Qiu M, Bulfone A, Ghattas I, Meneses JJ, Christensen L, Sharpe PT, Presley R, Pedersen RA, Rubenstein JL. Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches. Dev Biol. 1997 May 15; 185(2):165-84.
  255. Hernandez MC, Andres-Barquin PJ, Martinez S, Bulfone A, Rubenstein JL, Israel MA. ENC-1: a novel mammalian kelch-related gene specifically expressed in the nervous system encodes an actin-binding protein. J Neurosci. 1997 May 01; 17(9):3038-51.
  256. Ding M, Robel L, James AJ, Eisenstat DD, Leckman JF, Rubenstein JL, Vaccarino FM. Dlx-2 homeobox gene controls neuronal differentiation in primary cultures of developing basal ganglia. J Mol Neurosci. 1997 Apr; 8(2):93-113.
  257. Barondes SH, Alberts BM, Andreasen NC, Bargmann C, Benes F, Goldman-Rakic P, Gottesman I, Heinemann SF, Jones EG, Kirschner M, Lewis D, Raff M, Roses A, Rubenstein J, Snyder S, Watson SJ, Weinberger DR, Yolken RH. Workshop on schizophrenia. Proc Natl Acad Sci U S A. 1997 Mar 04; 94(5):1612-4.
  258. Shimamura K, Martinez S, Puelles L, Rubenstein JL. Patterns of gene expression in the neural plate and neural tube subdivide the embryonic forebrain into transverse and longitudinal domains. Dev Neurosci. 1997; 19(1):88-96.
  259. Qiu M, Anderson S, Chen S, Meneses JJ, Hevner R, Kuwana E, Pedersen RA, Rubenstein JL. Mutation of the Emx-1 homeobox gene disrupts the corpus callosum. Dev Biol. 1996 Aug 25; 178(1):174-8.
  260. McGuinness T, Porteus MH, Smiga S, Bulfone A, Kingsley C, Qiu M, Liu JK, Long JE, Xu D, Rubenstein JL. Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locus. Genomics. 1996 Aug 01; 35(3):473-85.
  261. Hartigan DJ, Rubenstein JL. The cDNA sequence of murine Nkx-2.2. Gene. 1996 Feb 12; 168(2):271-2.
  262. Fan CM, Kuwana E, Bulfone A, Fletcher CF, Copeland NG, Jenkins NA, Crews S, Martinez S, Puelles L, Rubenstein JL, Tessier-Lavigne M. Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome. Mol Cell Neurosci. 1996 Jan; 7(1):1-16.
  263. Shimamura K, Hartigan DJ, Martinez S, Puelles L, Rubenstein JL. Longitudinal organization of the anterior neural plate and neural tube. Development. 1995 Dec; 121(12):3923-33.
  264. Compagnone NA, Bulfone A, Rubenstein JL, Mellon SH. Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous system. Endocrinology. 1995 Nov; 136(11):5212-23.
  265. Qiu M, Bulfone A, Martinez S, Meneses JJ, Shimamura K, Pedersen RA, Rubenstein JL. Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain. Genes Dev. 1995 Oct 15; 9(20):2523-38.
  266. Bulfone A, Smiga SM, Shimamura K, Peterson A, Puelles L, Rubenstein JL. T-brain-1: a homolog of Brachyury whose expression defines molecularly distinct domains within the cerebral cortex. Neuron. 1995 Jul; 15(1):63-78.
  267. Zhu W, Dahmen J, Bulfone A, Rigolet M, Hernandez MC, Kuo WL, Puelles L, Rubenstein JL, Israel MA. Id gene expression during development and molecular cloning of the human Id-1 gene. Brain Res Mol Brain Res. 1995 Jun; 30(2):312-26.
  268. Compagnone NA, Bulfone A, Rubenstein JL, Mellon SH. Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis. Endocrinology. 1995 Jun; 136(6):2689-96.
  269. Thomas BL, Porteus MH, Rubenstein JL, Sharpe PT. The spatial localization of Dlx-2 during tooth development. Connect Tissue Res. 1995; 32(1-4):27-34.
  270. Porteus MH, Bulfone A, Liu JK, Puelles L, Lo LC, Rubenstein JL. DLX-2, MASH-1, and MAP-2 expression and bromodeoxyuridine incorporation define molecularly distinct cell populations in the embryonic mouse forebrain. J Neurosci. 1994 Nov; 14(11 Pt 1):6370-83.
  271. Rubenstein JL, Martinez S, Shimamura K, Puelles L. The embryonic vertebrate forebrain: the prosomeric model. Science. 1994 Oct 28; 266(5185):578-80.
  272. Rubenstein JL, Puelles L. Homeobox gene expression during development of the vertebrate brain. Curr Top Dev Biol. 1994; 29:1-63.
  273. Puelles L, Rubenstein JL. Expression patterns of homeobox and other putative regulatory genes in the embryonic mouse forebrain suggest a neuromeric organization. Trends Neurosci. 1993 Nov; 16(11):472-9.
  274. Bulfone A, Puelles L, Porteus MH, Frohman MA, Martin GR, Rubenstein JL. Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries. J Neurosci. 1993 Jul; 13(7):3155-72.
  275. Bulfone A, Kim HJ, Puelles L, Porteus MH, Grippo JF, Rubenstein JL. The mouse Dlx-2 (Tes-1) gene is expressed in spatially restricted domains of the forebrain, face and limbs in midgestation mouse embryos. Mech Dev. 1993 Mar; 40(3):129-40.
  276. Ozçelik T, Porteus MH, Rubenstein JL, Francke U. DLX2 (TES1), a homeobox gene of the Distal-less family, assigned to conserved regions on human and mouse chromosomes 2. Genomics. 1992 Aug; 13(4):1157-61.
  277. Porteus MH, Bulfone A, Ciaranello RD, Rubenstein JL. A partial cDNA sequence of the Dlx-2 cDNA. Neuron. 1992 Jul; 9(1):187.
  278. Porteus MH, Brice AE, Bulfone A, Usdin TB, Ciaranello RD, Rubenstein JL. Isolation and characterization of a library of cDNA clones that are preferentially expressed in the embryonic telencephalon. Brain Res Mol Brain Res. 1992 Jan; 12(1-3):7-22.
  279. Porteus MH, Bulfone A, Ciaranello RD, Rubenstein JL. Isolation and characterization of a novel cDNA clone encoding a homeodomain that is developmentally regulated in the ventral forebrain. Neuron. 1991 Aug; 7(2):221-9.
  280. Sanes JR, Rubenstein JL, Nicolas JF. Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos. EMBO J. 1986 Dec 01; 5(12):3133-42.
  281. Nicolas JF, Rubenstein JL, Bonnerot C, Jacob F. Introduction of genes into embryonal carcinoma cells and preimplantation embryos by retroviral vectors. Cold Spring Harb Symp Quant Biol. 1985; 50:713-20.
  282. Rubenstein JL, Nicolas JF, Jacob F. [Nonsense RNA: a tool for specifically inhibiting the expression of a gene in vivo]. C R Acad Sci III. 1984; 299(8):271-4.
  283. Rubenstein JL, Chappell TG. Construction of a synthetic messenger RNA encoding a membrane protein. J Cell Biol. 1983 May; 96(5):1464-9.
  284. Rubenstein JL, Fine RE, Luskey BD, Rothman JE. Purification of coated vesicles by agarose gel electrophoresis. J Cell Biol. 1981 May; 89(2):357-61.
  285. Smith LM, Rubenstein JL, Parce JW, McConnell HM. Lateral diffusion of M-13 coat protein in mixtures of phosphatidylcholine and cholesterol. Biochemistry. 1980 Dec 09; 19(25):5907-11.
  286. Rubenstein JL, Owicki JC, McConnell HM. Dynamic properties of binary mixtures of phosphatidylcholines and cholesterol. Biochemistry. 1980 Feb 05; 19(3):569-73.
  287. Rubenstein JL, Smith BA, McConnell HM. Lateral diffusion in binary mixtures of cholesterol and phosphatidylcholines. Proc Natl Acad Sci U S A. 1979 Jan; 76(1):15-8.
  288. Rubenstein JL, Brutlag D, Clayton DA. The mitochondrial DNA of Drosophila melanogaster exists in two distinct and stable superhelical forms. Cell. 1977 Oct; 12(2):471-82.
  289. Hruska JF, Clayton DA, Rubenstein JL, Robinson WS. Structure of hepatitis B Dane particle DNA before and after the Dane particle DNA polymerase reaction. J Virol. 1977 Feb; 21(2):666-72.

Books and Other Publications

Invited Reviews and Book Chapters

1988                Nicolas, J.F., and Rubenstein, J.L.R. Retroviral Vectors.  In: Vectors: a Survey of Molecular Cloning Vectors and Their Uses.  Rodriguez, R. and Denhardt, D.T. (eds)  Butterworth, 1988. (book chapter)

1990                Rubenstein, J.L.R., Lotspeich, L. and Ciaranello, R.D.  The neurobiology of developmental disorders. from: Advances in Clinical Child Psychology, vol 13, ed: B.B. Lahey and A.E. Kazdin.  Plenum Press. 1-52, 1990. (book chapter)

1990                Ciaranello, R.D., Wong, D.L. and Rubenstein, J.L.R.   Molecular neurobiology and disorders of brain development. from: Application of Basic Neuroscience to Child Psychiatry. ed:  S.I. Deutsch, A. Weizman, and R. Weizman.  Plenum Press. 9-32, 1990. (book chapter)

1994                Rubenstein, J.L.R. and Puelles, L. Homeobox gene expression during development of the vertebrate brain. Current Topics in Developmental Biology. ed. R. Pederson. Academic Press. 29, 1-64 .

1994                Rubenstein, J.L.R. Gene Cloning. from: Molecular Medicine. ed: E. Rubenstein. Scientific American Medicine, 103-132. Note: This book won the 1995 British Medical Association Medical Book of the Year Award and First Prize for the Best Basic and Clinical Sciences Book.

1988                        Rubenstein, J.L.R. (1998). Development of serotonergic neurons and their projections. Biol. Psych. 44, 145-150.

1998             Rubenstein, J.L.R.  (1998). Images in neuroscience. Brain development I. The neural plate.  American Journal of Psychiatry, 155(3):324.

1998                        Rubenstein J.L.R.  (1998) Development of the cerebral cortex: V. Transcription factors and brain development. Journal of the American Academy of Child and Adolescent Psychiatry, 37(5):561-562.

1999                Rubenstein, J.L.R. Overview of brain development. In: The Neurobiology of Mental Illness. D. Charney, E.J. Nestler, B.S. Bunney, Eds. Oxford University Press. New York, New York, Chapter 1.

1999                        Rubenstein, J.L.R. and Rakic, P. (1999). Genetic control of cortical development. Cerebral Cortex. 9: 521-523.

2000                Rubenstein, J.L.R. (2000) Intrinsic and Extrinsic Control of Cortical Development. Novartis Symposium 228: Evolutionary Developmental Biology of the Cerebral Cortex. Wiley, 67-74.

2000                        Parnavelas, J.G., Anderson, SA, Lavdas, AA, Grigoriou, M.. Pachnis V. and Rubenstein, J.L.R. (2000). The contribution of the ganglionic eminence to the neuronal cell types of the cerebral cortex. Novartis Symposium 228: Evolutionary Developmental Biology of the Cerebral Cortex. Wiley, 129-138.

2002             Puelles, L. and Rubenstein, J.L.R. (2002). Forebrain. Encyclopedia of the human brain. Academic Press, vol 2, 289-315.

2002                        Marin, O.  and Rubenstein, J.L.R. (2002). Patterning, regionalization and cell differentiation in the forebrain. In: Mouse Development, Editors: J. Rossant and P. Tam. Academic Press. 75-106.

2003                        Rubenstein, JLR and Puelles, L. (2003) Development of the Nervous System. For: Molecular Basis Of Inborn Errors of Development. Epstein CJ, Erikson RP and Wynshaw-Boris A, editors. Oxford University Press. Chapter 8.

2003                        Belmonte, MK, EH Cook, GM Anderson, JLR Rubenstein, WT Greenough,

A Beckel-Mitchener, E Courchesne, LM Boulanger, SB Powell, PR Levitt, EK Perry, Y Jiang, TM DeLorey, E Tierney. (2003). Autism as a Disorder of Neural Information Processing: Directions for Research and Targets for Therapy. Molecular Psychiatry. 9(7):646-663.

2004 Garel, S. and Rubenstein, JLR. (2004) Patterning of the Cerebral Cortex. The Cognitive Neurosciences, 3rd edition. Michael S. Gazzaniga Editor-in-Chief. MIT Press. November 2004.

2004                Puelles, L, Martínez S, and Rubenstein JLR. Gene maps and related histogenetic domains in the forebrain and midbrain. Chapter 1, The Rat Nervous System. Third Edition. Ed. Paxinos, Elsevier-Academic Press. pp. 3-25.

2004                Rubenstein, JLR and Puelles, L. (2004) Survey of Brain Development. Handbook of Mental Health Interventions in Children and Adolescents. Steiner, H, editor. Jossey-Bass Press. Chapter 5.

2006                        Understanding Autism: From Basic Neuroscience to Treatment (Book). Edited by Steven O. Moldin, John L. R. Rubenstein. CRC Press, 2006.

2006                        Moldin, SO, Rubenstein, JLR, Hyman, SE. (2006). Autism Speaks to Neuroscience. Commentary in: J. Neuroscience. 26(26):6893-6

2007                        Cholfin JA, Rubenstein JL. Genetic regulation of prefrontal cortex development and function.  Novartis Found Symp. 2007;288:165-73; discussion 173-7, 276-81.

2008                        Rubenstein, JLR and Puelles, L. (2008) Development of the Nervous System. Molecular Basis Of Inborn Errors of Development. Second Edition. Epstein CJ, Erikson RP and Wynshaw-Boris A, editors. Oxford University Press. Chapter 7.

2009                        Hoch, RV, Rubenstein JLR, Pleasure S. (2009). Genes and signaling events that establish regional patterning of the mammalian forebrain.  Seminars in Cell and Developmental Biology. 20(4):378-8

2010                        Rubenstein JL, (2010). Annual Research Review: Development of the cerebral cortex: implications for neurodevelopmental disorders. J Child Psychol Psychiatry. 2010. 52(4):339-55.

2011                        Tabarés-Seisdedos R, Dumont N, Baudot A, Valderas JM, Climent J, Valencia A, Crespo-Facorro B, Vieta E, Gómez-Beneyto M, Martínez S, Rubenstein JL. No paradox, no progress: inverse cancer comorbidity in people with other complex diseases. Lancet Oncol. 2011 Jun;12(6):604-8.

2011                        Messing RO, Rubenstein JL, Nestler E. (2011) Biology of Psychiatric Disorders, Harrisons Principles of Internal Medicine, 18th edition.  Eds: Dan L. Longo, Dennis L. Kasper, J. Larry Jameson, Anthony S. Fauci, Stephen L. Hauser, Joseph Loscalzo. Chapter 390. 2011.

2012                        Gelman DM, Marín O. Rubenstein JLR. (2012) The Generation of Cortical Interneurons. Section IV - Genetics" of Jasper's Basic Mechanisms of the Epilepsies; Fr: Editors of Jasper's Basic Mechanisms of the Epilepsies (J. Noebels, M. Avoli, M. Rogawski, R. Olsen, A.V. Delgado-Escueta). Oxford University Press.  786-796.

2013                Rubenstein JLR and Rakic P (editors in chief) (2013) Comprehensive Developmental Neuroscience. Academic Press, Three Volumes.